loading...| Preferred Name |
Lamivudine/Zidovudine |
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| Synonyms |
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| Definitions |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C28939 |
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| code |
C28939 |
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| Concept_Status |
Obsolete_Concept |
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| definition |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
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| label |
Lamivudine/Zidovudine |
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| Legacy Concept Name |
Lamivudine_Zidovudine |
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| Preferred_Name |
Lamivudine/Zidovudine |
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| prefixIRI |
NCIT:C28939 |
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| prefLabel |
Lamivudine/Zidovudine |
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| Semantic_Type |
Therapeutic or Preventive Procedure |
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| UMLS_CUI |
C0717880 |
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| subClassOf |