Preferred Name |
Chloral Hydrate |
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Synonyms |
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Definitions |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. |
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ID |
http://purl.obolibrary.org/obo/NCIT_C28922 |
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CAS_Registry |
302-17-0 |
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CHEBI_ID |
CHEBI:28142 |
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Chemical_Formula |
C2H3Cl3O2 |
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code |
C28922 |
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Contributing_Source |
FDA |
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definition |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. |
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FDA_UNII_Code |
418M5916WG |
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in_subset | ||
label |
Chloral Hydrate |
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Legacy Concept Name |
Chloral_Hydrate |
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Preferred_Name |
Chloral Hydrate |
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prefixIRI |
NCIT:C28922 |
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prefLabel |
Chloral Hydrate |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0008161 |
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subClassOf |