loading...| Preferred Name |
Cefpodoxime Proxetil |
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| Synonyms |
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|
| Definitions |
A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C28916 |
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| CAS_Registry |
87239-81-4 |
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| CHEBI_ID |
CHEBI:3505 |
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| code |
C28916 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation. |
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| Display_Name |
Cefpodoxime Proxetil |
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| FDA_UNII_Code |
2TB00A1Z7N |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Cefpodoxime Proxetil |
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| Legacy Concept Name |
Cefpodoxime |
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| NCI_Drug_Dictionary_ID |
455227 |
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| PDQ_Closed_Trial_Search_ID |
455227 |
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| PDQ_Open_Trial_Search_ID |
455227 |
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| Preferred_Name |
Cefpodoxime Proxetil |
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| prefixIRI |
NCIT:C28916 |
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| prefLabel |
Cefpodoxime Proxetil |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0108938 |
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| subClassOf |