loading...| Preferred Name |
Lenalidomide |
|
| Synonyms |
|
|
| Definitions |
A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2668 |
|
| Accepted_Therapeutic_Use_For |
Transfusion-dependent anemia due to low- or intermediate-1 risk myelodysplastic syndrome; multiple myeloma, lymphoma |
|
| ALT_DEFINITION |
A drug that is similar to thalidomide, and is used to treat multiple myeloma and certain types of anemia. It is also being studied in the treatment of other types of cancer. Lenalidomide belongs to the family of drugs called angiogenesis inhibitors. |
|
| CAS_Registry |
191732-72-6 |
|
| CHEBI_ID |
CHEBI:63791 |
|
| Chemical_Formula |
C13H13N3O3 |
|
| code |
C2668 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. |
|
| Display_Name |
Lenalidomide |
|
| FDA_UNII_Code |
F0P408N6V4 |
|
| Has_Target |
http://purl.obolibrary.org/obo/NCIT_C20450 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Lenalidomide |
|
| Legacy Concept Name |
CC-5013 |
|
| Maps_To |
Lenalidomide |
|
| NCI_Drug_Dictionary_ID |
38564 |
|
| NSC Number |
703813 |
|
| PDQ_Closed_Trial_Search_ID |
38564 |
|
| PDQ_Open_Trial_Search_ID |
38564 |
|
| Preferred_Name |
Lenalidomide |
|
| prefixIRI |
NCIT:C2668 |
|
| prefLabel |
Lenalidomide |
|
| PubMedID_Primary_Reference |
16085014 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C1144149 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C157388 |