loading...| Preferred Name |
Sildenafil Citrate |
|
| Synonyms |
|
|
| Definitions |
The citrate salt form of sildenafil, an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C26670 |
|
| Accepted_Therapeutic_Use_For |
Pulmonary hypertension Erectile dysfunction |
|
| ALT_DEFINITION |
A drug used to treat erectile dysfunction. Viagra relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor. |
|
| CAS_Registry |
171599-83-0 |
|
| CHEBI_ID |
CHEBI:58987 |
|
| Chemical_Formula |
C22H30N6O4S.C6H8O7 |
|
| code |
C26670 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The citrate salt form of sildenafil, an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production. |
|
| Display_Name |
Sildenafil Citrate |
|
| FDA_UNII_Code |
BW9B0ZE037 |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C107631 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Sildenafil Citrate |
|
| Legacy Concept Name |
Sildenafil_Citrate |
|
| NCI_Drug_Dictionary_ID |
269137 |
|
| PDQ_Closed_Trial_Search_ID |
269137 |
|
| PDQ_Open_Trial_Search_ID |
269137 |
|
| Preferred_Name |
Sildenafil Citrate |
|
| prefixIRI |
NCIT:C26670 |
|
| prefLabel |
Sildenafil Citrate |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0724693 |
|
| subClassOf |