loading...| Preferred Name |
Donepezil Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2603 |
|
| Accepted_Therapeutic_Use_For |
Alzheimers disease and opioid-induced sedation. |
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| CAS_Registry |
120011-70-3 142057-77-0 |
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| CHEBI_ID |
CHEBI:4696 |
|
| Chemical_Formula |
C24H29NO3.HCl |
|
| code |
C2603 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. |
|
| Display_Name |
Donepezil Hydrochloride |
|
| FDA_UNII_Code |
3O2T2PJ89D |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Donepezil Hydrochloride |
|
| Legacy Concept Name |
Donepezil |
|
| NCI_Drug_Dictionary_ID |
38109 |
|
| PDQ_Closed_Trial_Search_ID |
38109 |
|
| PDQ_Open_Trial_Search_ID |
38109 |
|
| Preferred_Name |
Donepezil Hydrochloride |
|
| prefixIRI |
NCIT:C2603 |
|
| prefLabel |
Donepezil Hydrochloride |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0771848 |
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| subClassOf |