loading...| Preferred Name |
Psoralen |
|
| Synonyms |
|
|
| Definitions |
A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2586 |
|
| Accepted_Therapeutic_Use_For |
Psoriasis; T-cell Lymphoma-Cutaneous; Vitiligo |
|
| ALT_DEFINITION |
A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen. |
|
| CAS_Registry |
66-97-7 |
|
| CHEBI_ID |
CHEBI:27616 |
|
| Chemical_Formula |
C11H6O3 |
|
| code |
C2586 |
|
| Contributing_Source |
FDA |
|
| definition |
A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids. |
|
| FDA_UNII_Code |
KTZ7ZCN2EX |
|
| in_subset | ||
| label |
Psoralen |
|
| Legacy Concept Name |
Psoralen |
|
| NCI_Drug_Dictionary_ID |
37899 |
|
| NSC Number |
217989 |
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| PDQ_Closed_Trial_Search_ID |
37899 |
|
| PDQ_Open_Trial_Search_ID |
37899 |
|
| Preferred_Name |
Psoralen |
|
| prefixIRI |
NCIT:C2586 |
|
| prefLabel |
Psoralen |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0016072 |
|
| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C2163 |