loading...| Preferred Name |
Arginine Butyrate |
|
| Synonyms |
|
|
| Definitions |
The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2570 |
|
| ALT_DEFINITION |
A substance that is being studied as a treatment for cancer. |
|
| CAS_Registry |
80407-72-3 |
|
| Chemical_Formula |
3C6H14N4O2.4C4H8O2 |
|
| code |
C2570 |
|
| Contributing_Source |
FDA |
|
| definition |
The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. (NCI04) |
|
| FDA_UNII_Code |
IK8S1P79MU |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Arginine Butyrate |
|
| Legacy Concept Name |
Arginine_Butyrate |
|
| Maps_To |
Arginine Butyrate |
|
| NCI_Drug_Dictionary_ID |
42492 |
|
| PDQ_Closed_Trial_Search_ID |
42492 |
|
| PDQ_Open_Trial_Search_ID |
42492 |
|
| Preferred_Name |
Arginine Butyrate |
|
| prefixIRI |
NCIT:C2570 |
|
| prefLabel |
Arginine Butyrate |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0052329 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2570 | NCIT | LOOM | |
| http://purl.bioontology.org/ontology/PDQ/CDR0000042492 | PDQ | LOOM | |
| http://phenomebrowser.net/ontologies/mesh/mesh.owl#C033018 | RH-MESH | LOOM | |
| http://purl.bioontology.org/ontology/MESH/C033018 | MESH | LOOM |