Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Pegylated Interferon Alfa
Synonyms
Definitions

A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
ID

http://purl.obolibrary.org/obo/NCIT_C2491
Accepted_Therapeutic_Use_For

Hepatitis C.
code

C2491
Contributing_Source

CTRP
definition

A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
Display_Name

Pegylated Interferon Alfa
in_subset

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Pegylated Interferon Alfa
Legacy Concept Name

Pegylated_Interferon_Alfa
Maps_To

Pegylated Interferon Alfa
NCI_Drug_Dictionary_ID

43151
PDQ_Closed_Trial_Search_ID

43151
PDQ_Open_Trial_Search_ID

43151
Preferred_Name

Pegylated Interferon Alfa
prefixIRI

NCIT:C2491
prefLabel

Pegylated Interferon Alfa
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0907160
subClassOf

http://purl.obolibrary.org/obo/NCIT_C225
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