loading...| Preferred Name |
5 Alpha-Reductase Inhibitor |
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| Synonyms |
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| Definitions |
Any substance that inhibits steroid 5-alpha-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). Since DHT has three times greater affinity for androgen receptors than testosterone, inhibition of 5-alpha-reductase results in a strong reduction in the androgenic effects of testosterone. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2319 |
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| ALT_DEFINITION |
A substance that blocks an enzyme needed by the body to make dihydrotestosterone (a male sex hormone made from testosterone). Dihydrotestosterone can cause the prostate to grow. 5-alpha reductase inhibitors are used to shrink an enlarged prostate gland and to improve the flow of urine in a condition called benign prostatic hyperplasia (BPH). A 5-alpha reductase inhibitor is a type of enzyme inhibitor. |
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| CHEBI_ID |
CHEBI:50781 |
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| code |
C2319 |
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| definition |
Any substance that inhibits steroid 5-alpha-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). Since DHT has three times greater affinity for androgen receptors than testosterone, inhibition of 5-alpha-reductase results in a strong reduction in the androgenic effects of testosterone. |
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| label |
5 Alpha-Reductase Inhibitor |
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| Legacy Concept Name |
_5_Alpha-Reductase_Inhibitor |
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| Preferred_Name |
5 Alpha-Reductase Inhibitor |
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| prefixIRI |
NCIT:C2319 |
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| prefLabel |
5 Alpha-Reductase Inhibitor |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C1318898 |
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| subClassOf |
http://purl.obolibrary.org/obo/NCIT_C1892 |