loading...| Preferred Name |
Prasterone |
|
| Synonyms |
|
|
| Definitions |
A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C2265 |
|
| Accepted_Therapeutic_Use_For |
Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction |
|
| ALT_DEFINITION |
A substance being studied in the prevention of cancer. It is a type of steroid. |
|
| CAS_Registry |
53-43-0 |
|
| CHEBI_ID |
CHEBI:28689 |
|
| Chemical_Formula |
C19H28O2 |
|
| code |
C2265 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04) |
|
| Display_Name |
Prasterone |
|
| FDA_UNII_Code |
459AG36T1B |
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Prasterone |
|
| Legacy Concept Name |
Therapeutic_Dehydroepiandrosterone |
|
| NCI_Drug_Dictionary_ID |
42419 |
|
| NSC Number |
9896 |
|
| PDQ_Closed_Trial_Search_ID |
42419 |
|
| PDQ_Open_Trial_Search_ID |
42419 |
|
| Preferred_Name |
Prasterone |
|
| prefixIRI |
NCIT:C2265 |
|
| prefLabel |
Prasterone |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0011185 |
|
| subClassOf |