loading...| Preferred Name |
Thymidylate Synthase Inhibitor |
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| Synonyms |
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| Definitions |
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2021 |
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| ALT_DEFINITION |
A drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer. |
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| CHEBI_ID |
CHEBI:63720 |
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| code |
C2021 |
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| definition |
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation. |
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| label |
Thymidylate Synthase Inhibitor |
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| Legacy Concept Name |
Thymidylate_Synthase_Inhibitor |
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| Preferred_Name |
Thymidylate Synthase Inhibitor |
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| prefixIRI |
NCIT:C2021 |
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| prefLabel |
Thymidylate Synthase Inhibitor |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1373008 |
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| subClassOf |