loading...| Preferred Name |
Evolocumab |
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| Synonyms |
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| Definitions |
A human immunoglobulin G2 (IgG2) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, evolocumab targets, binds to and inhibits the activity of PCSK9. This prevents binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C174672 |
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| CAS_Registry |
1256937-27-5 |
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| code |
C174672 |
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| Contributing_Source |
FDA |
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| definition |
A human immunoglobulin G2 (IgG2) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, evolocumab targets, binds to and inhibits the activity of PCSK9. This prevents binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver. |
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| FDA_UNII_Code |
LKC0U3A8NJ |
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| in_subset | ||
| label |
Evolocumab |
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| NCI_Drug_Dictionary_ID |
808340 |
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| NCI_META_CUI |
CL1412172 |
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| Preferred_Name |
Evolocumab |
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| prefixIRI |
NCIT:C174672 |
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| prefLabel |
Evolocumab |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| subClassOf |