loading...| Preferred Name |
Ursolic Acid |
|
| Synonyms |
|
|
| Definitions |
A pentacyclic triterpenoid found in various fruits, vegetables and medicinal herbs, with a variety of potential pharmacologic activities including anti-inflammatory, antioxidative, antiviral, serum lipid-lowering, and antineoplastic activities. Upon administration, ursolic acid may promote apoptosis and inhibit cancer cell proliferation through multiple mechanisms. This may include the regulation of mitochondrial function through various pathways including the ROCK/PTEN and p53 pathways, the suppression of the nuclear factor-kappa B (NF-kB) pathways, and the increase in caspase-3, caspase-8 and caspase-9 activities. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C172843 |
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| CAS_Registry |
77-52-1 |
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| code |
C172843 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A pentacyclic triterpenoid found in various fruits, vegetables and medicinal herbs, with a variety of potential pharmacologic activities including anti-inflammatory, antioxidative, antiviral, serum lipid-lowering, and antineoplastic activities. Upon administration, ursolic acid may promote apoptosis and inhibit cancer cell proliferation through multiple mechanisms. This may include the regulation of mitochondrial function through various pathways including the ROCK/PTEN and p53 pathways, the suppression of the nuclear factor-kappa B (NF-kB) pathways, and the increase in caspase-3, caspase-8 and caspase-9 activities. |
|
| Display_Name |
Ursolic Acid |
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| FDA_UNII_Code |
P3M2575F3F |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Ursolic Acid |
|
| Maps_To |
Ursolic Acid |
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| NCI_Drug_Dictionary_ID |
801981 |
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| NCI_META_CUI |
CL1406899 |
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| PDQ_Closed_Trial_Search_ID |
801981 |
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| PDQ_Open_Trial_Search_ID |
801981 |
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| Preferred_Name |
Ursolic Acid |
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| prefixIRI |
NCIT:C172843 |
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| prefLabel |
Ursolic Acid |
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| Semantic_Type |
Pharmacologic Substance |
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| subClassOf |