loading...| Preferred Name |
Bexarotene |
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| Synonyms |
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|
| Definitions |
A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1635 |
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| Accepted_Therapeutic_Use_For |
Oral or topical treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL). |
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| ALT_DEFINITION |
A drug used to treat skin problems caused by cutaneous T-cell lymphoma that have not gotten better after other treatment. It is also being studied in the treatment of other types of cancer. Bexarotene is a type of retinoid. |
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| CAS_Registry |
153559-49-0 |
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| CHEBI_ID |
CHEBI:50859 |
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| Chemical_Formula |
C24H28O2 |
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| code |
C1635 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04) |
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| Display_Name |
Bexarotene |
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| FDA_UNII_Code |
A61RXM4375 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Bexarotene |
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| Legacy Concept Name |
Bexarotene |
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| Maps_To |
Bexarotene |
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| NCI_Drug_Dictionary_ID |
42117 |
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| PDQ_Closed_Trial_Search_ID |
42117 |
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| PDQ_Open_Trial_Search_ID |
42117 |
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| Preferred_Name |
Bexarotene |
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| prefixIRI |
NCIT:C1635 |
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| prefLabel |
Bexarotene |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0765273 |
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| subClassOf |