Preferred Name |
Eflornithine Hydrochloride |
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Synonyms |
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Definitions |
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04) |
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ID |
http://purl.obolibrary.org/obo/NCIT_C1579 |
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CAS_Registry |
96020-91-6 |
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Chemical_Formula |
C6H12F2N2O2.HCl.H2O |
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code |
C1579 |
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Contributing_Source |
CTRP FDA |
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definition |
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04) |
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Display_Name |
Eflornithine Hydrochloride |
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FDA_UNII_Code |
4NH22NDW9H |
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Has_Free_Acid_Or_Base_Form | ||
Has_Target | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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Is_Value_For_GDC_Property | ||
label |
Eflornithine Hydrochloride |
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Legacy Concept Name |
Eflornithine_Hydrochloride |
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Maps_To |
Eflornithine Hydrochloride |
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NCI_Drug_Dictionary_ID |
39754 |
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NSC Number |
270295 337250 |
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PDQ_Closed_Trial_Search_ID |
39754 |
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PDQ_Open_Trial_Search_ID |
39754 |
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Preferred_Name |
Eflornithine Hydrochloride |
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prefixIRI |
NCIT:C1579 |
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prefLabel |
Eflornithine Hydrochloride |
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Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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UMLS_CUI |
C0282042 |
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subClassOf |