Preferred Name |
Secukinumab |
|
Synonyms |
|
|
Definitions |
A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C152315 |
|
CAS_Registry |
1229022-83-6 |
|
code |
C152315 |
|
Contributing_Source |
FDA |
|
definition |
A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response. |
|
FDA_UNII_Code |
DLG4EML025 |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
|
label |
Secukinumab |
|
NCI_Drug_Dictionary_ID |
803239 |
|
NCI_META_CUI |
CL553647 |
|
PDQ_Closed_Trial_Search_ID |
803239 |
|
PDQ_Open_Trial_Search_ID |
803239 |
|
Preferred_Name |
Secukinumab |
|
prefixIRI |
NCIT:C152315 |
|
prefLabel |
Secukinumab |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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subClassOf |