loading...| Preferred Name |
Lamivudine |
|
| Synonyms |
|
|
| Definitions |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1471 |
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| Accepted_Therapeutic_Use_For |
Chronic hepatitis B; HIV infection |
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| ALT_DEFINITION |
A drug used to treat infection caused by viruses. |
|
| CAS_Registry |
134678-17-4 |
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| CHEBI_ID |
CHEBI:63577 |
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| Chemical_Formula |
C8H11N3O3S |
|
| code |
C1471 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04) |
|
| Display_Name |
Lamivudine |
|
| FDA_UNII_Code |
2T8Q726O95 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Lamivudine |
|
| Legacy Concept Name |
Lamivudine |
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| NCI_Drug_Dictionary_ID |
42593 |
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| PDQ_Closed_Trial_Search_ID |
42593 |
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| PDQ_Open_Trial_Search_ID |
42593 |
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| Preferred_Name |
Lamivudine |
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| prefixIRI |
NCIT:C1471 |
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| prefLabel |
Lamivudine |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0209738 |
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| subClassOf |