loading...| Preferred Name |
Fulvestrant |
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| Synonyms |
|
|
| Definitions |
A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1379 |
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| Accepted_Therapeutic_Use_For |
Hormone receptor-positive metastatic breast cancer |
|
| ALT_DEFINITION |
A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen. |
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| CAS_Registry |
129453-61-8 |
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| CHEBI_ID |
CHEBI:31638 |
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| Chemical_Formula |
C32H47F5O3S |
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| code |
C1379 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04) |
|
| Display_Name |
Fulvestrant |
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| FDA_UNII_Code |
22X328QOC4 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Fulvestrant |
|
| Legacy Concept Name |
Fulvestrant |
|
| Maps_To |
Fulvestrant |
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| NCI_Drug_Dictionary_ID |
43053 |
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| NSC Number |
719276 |
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| PDQ_Closed_Trial_Search_ID |
43053 |
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| PDQ_Open_Trial_Search_ID |
43053 |
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| Preferred_Name |
Fulvestrant |
|
| prefixIRI |
NCIT:C1379 |
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| prefLabel |
Fulvestrant |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0935916 |
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| subClassOf |