loading...| Preferred Name |
Oprelvekin |
|
| Synonyms |
|
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1303 |
|
| Accepted_Therapeutic_Use_For |
Chemotherapy-related thrombocytopenia |
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| ALT_DEFINITION |
A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Neumega is a form of interleukin-11 (a cytokine normally made by support cells in the bone marrow) that is made in the laboratory. It is a type of biological response modifier. |
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| CAS_Registry |
145941-26-0 |
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| code |
C1303 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04) |
|
| Display_Name |
Oprelvekin |
|
| FDA_UNII_Code |
HM5641GA6F |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Oprelvekin |
|
| Legacy Concept Name |
Therapeutic_Interleukin-11 |
|
| NCI_Drug_Dictionary_ID |
42365 |
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| PDQ_Closed_Trial_Search_ID |
42365 |
|
| PDQ_Open_Trial_Search_ID |
42365 |
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| Preferred_Name |
Oprelvekin |
|
| prefixIRI |
NCIT:C1303 |
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| prefLabel |
Oprelvekin |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
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| UMLS_CUI |
C0537670 |
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| subClassOf |