loading...| Preferred Name |
Ceritinib |
|
| Synonyms |
|
|
| Definitions |
An orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C115112 |
|
| Accepted_Therapeutic_Use_For |
metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive |
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| CAS_Registry |
1032900-25-6 |
|
| code |
C115112 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
An orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types. |
|
| Display_Name |
Ceritinib |
|
| FDA_UNII_Code |
K418KG2GET |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Ceritinib |
|
| Maps_To |
Ceritinib |
|
| NCI_Drug_Dictionary_ID |
694589 |
|
| PDQ_Closed_Trial_Search_ID |
694589 |
|
| PDQ_Open_Trial_Search_ID |
694589 |
|
| Preferred_Name |
Ceritinib |
|
| prefixIRI |
NCIT:C115112 |
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| prefLabel |
Ceritinib |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3818721 |
|
| subClassOf |