loading...| Preferred Name |
Venetoclax |
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| Synonyms |
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|
| Definitions |
An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C103147 |
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| Accepted_Therapeutic_Use_For |
chronic lymphocytic leukemia (CLL) with 17p deletion and or small lymphocytic lymphoma (SLL) |
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| CAS_Registry |
1257044-40-8 |
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| code |
C103147 |
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| Contributing_Source |
CTRP FDA |
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| definition |
An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia. |
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| Display_Name |
Venetoclax |
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| FDA_UNII_Code |
N54AIC43PW |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Venetoclax |
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| Maps_To |
Venetoclax |
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| NCI_Drug_Dictionary_ID |
698675 |
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| PDQ_Closed_Trial_Search_ID |
698675 |
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| PDQ_Open_Trial_Search_ID |
698675 |
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| Preferred_Name |
Venetoclax |
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| prefixIRI |
NCIT:C103147 |
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| prefLabel |
Venetoclax |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C3659811 |
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| subClassOf |