loading...| Preferred Name |
colistin |
|
| Synonyms |
Colistin polymyxin E colistina colistine colistinum |
|
| Definitions |
A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_37943 |
|
| charge |
0 |
|
| database_cross_reference |
DrugBank:DB00803 PMID:26488563 PMID:17576842 PMID:17620384 PMID:28018876 PMID:28029008 PMID:28257552 CAS:1264-72-8 PMID:27790432 PMID:28321410 PMID:27411324 PMID:27524102 PMID:17846127 PMID:26252512 PMID:28267594 PMID:18625681 PMID:17145797 PMID:25322351 KEGG:D02138 PMID:17876007 PMID:15825037 PMID:28215823 PMID:27552304 PMID:16931410 PMID:28267779 PMID:26730548 PMID:28315729 CAS:1066-17-7 PMID:27917926 PMID:27684296 PMID:17562800 PMID:27480806 PMID:27743779 PMID:17606684 PMID:27793510 PMID:17646423 PMID:28300674 PMID:27160031 PMID:26415906 KEGG:C13768 PMID:27891118 |
|
| definition |
A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa. |
|
| formula |
C52H97N16O13R |
|
| has part | ||
| has_alternative_id |
CHEBI:34651 CHEBI:472593 CHEBI:600596 CHEBI:560465 CHEBI:597111 CHEBI:566816 CHEBI:659853 CHEBI:596826 |
|
| has_exact_synonym |
Colistin |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
polymyxin E colistina colistine colistinum |
|
| id |
CHEBI:37943 |
|
| in_subset | ||
| label |
colistin |
|
| mass |
1154.428 |
|
| monoisotopicmass |
1153.74210 |
|
| notation |
CHEBI:37943 |
|
| prefLabel |
colistin |
|
| RO_0000087 | ||
| smiles |
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C |
|
| subClassOf |