loading...| Preferred Name |
Chlorpromazine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassb4b1c98b_9390_416c_935b_7b37d4b9923f |
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| Chinese |
氯丙嗪 |
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| label |
Chlorpromazine |
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| MESH_Definition |
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. |
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| NCIt_Definition |
A phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting. |
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| prefLabel |
Chlorpromazine |
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| Synonyms |
CHLORPROMAZINE 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlor-PZ Chlorpromazine (substance) 3-(2-chloro-10H-phenothiazin-10-yl)-NN-dimethyl-1-propanamine Chlorpromazine-containing product 10H-Phenothiazine-10-propanamine 2-chloro-NN-dimethyl- Chlorpromazinum CPZ 167745 50-53-3 Product containing chlorpromazine (medicinal product) Thorazine 3-(2-chlorophenothiazin-10-yl)-NN-dimethyl-propan-1-amine N-(3-dimethylaminopropyl)-3-chlorophenothiazine Clorpromazina |
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| subClassOf |