loading...| Preferred Name |
Pimozide |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass9a12dad9_5bb9_41cc_8673_21bf0288c0c0 |
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| Chinese |
匹莫齐特 |
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| MESH_Definition |
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403) |
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| NCIt_Definition |
A diphenylbutylpiperidine derivative and a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors. |
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| prefLabel |
Pimozide |
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| Synonyms |
Product containing pimozide (medicinal product) Pimozida 2H-Benzimidazol-2-one 1-(1-(44-bis(4-fluorophenyl)butyl)-4-piperidinyl)-13-dihydro- Orap Pimozidum Pimozide Pimozide-containing product Orap forte Opiran Pimozide (substance) |
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