Preferred Name |
Primidone |
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Synonyms |
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ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass76015179_8020_45db_b3da_5ef495ffcf72 |
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Chinese |
扑痫酮 |
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label |
Primidone |
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MESH_Definition |
A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. |
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NCIt_Definition |
An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties. |
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prefLabel |
Primidone |
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ROCG_Guidance |
[GRADES OF RECOMMENDATION:C] Women taking enzyme-inducing AEDs (carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate and eslicarbazepine) should be counselled about the risk of failure with some hormonal contraceptives. 【推荐等级:C】应告知服用酶诱导型AEDs(卡马西平、苯妥英、苯巴比妥、扑米酮、奥卡西平、托吡酯、艾司利卡西平)的WWE避孕失败的风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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SIGN_Guidance |
[GRADES OF RECOMMENDATION:D] Parents should be made aware of signs of toxicity in infants of breastfeeding women taking antiepileptic drugs. The possibility of sedation should be considered in infants of mothers taking high dose antiepileptic drugs, polytherapy, or regimens including primidone, levetiracetam, gabapentin, lamotrigine and topiramate. D级推荐:应告知女性癫痫患者及其伴侣,哺乳期服用AEDs可能对新生儿/婴儿有不良影响。服用大剂量AEDs、综合疗法或采用包含扑米酮、左乙拉西坦、加巴喷丁、拉莫三嗪和托吡酯在内的治疗方案的哺乳期母亲婴儿可能会有镇静的副作用。 Scottish Intercollegiate Guidelines Network.Diagnosis and management of epilepsy in adults. SIGN 143. Edinburgh, SIGN, 2015. Available at: www.sign.ac.uk/guidelines/fulltext/143/index.html |
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Synonyms |
5-Phenyl-5-ethyl-Hexahydropyrimidine-46-dione Primidonum Primidone Mysedon Primidon 2-Deoxyphenobarbital 46(1H5H)-Pyrimidinedione 5-ethyldihydro-5-phenyl- Primaclone Primidona Myidone Primidone-containing product Desoxyphenobarbital Primidone (substance) Product containing primidone (medicinal product) Mysoline Apo-Primidone Neurosyn Misodine Mysoline Mylepsinum Resimatil Liskantin Mizodin Sertan Primidon Holsten Apo Primidone Apo-Primidone |
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subClassOf |