loading...| Preferred Name |
Carbamazepine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass612b1b7c_845d_4c86_b2db_6ce55c8d2beb |
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| Chinese |
卡马西平 |
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| label |
Carbamazepine |
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| MESH_Definition |
A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties. |
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| NCIt_Definition |
A tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia. |
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| prefLabel |
Carbamazepine |
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| ROCG_Guidance |
[GRADES OF RECOMMENDATION:C] Based on limited evidence, in utero exposure to carbamazepine and lamotrigine does not appear to adversely affect neurodevelopment of the offspring. There is very little evidence for levetiracetam and phenytoin. Parents should be informed that evidence on long-term outcomes is based on small numbers of children. 【推荐等级：C】应告知WWE及其伴侣，关于宫内暴露于AEDs产生的长期神经发育结果是基于少数儿童的。有限的证据表示，宫内接触CBZ和LTG似乎不会影响后代神经生长发育；使用LEV和PHT的证据很少。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ [GRADES OF RECOMMENDATION:C] Women taking enzyme-inducing AEDs (carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate and eslicarbazepine) should be counselled about the risk of failure with some hormonal contraceptives. 【推荐等级：C】应告知服用酶诱导型AEDs（卡马西平、苯妥英、苯巴比妥、扑米酮、奥卡西平、托吡酯、艾司利卡西平）的WWE避孕失败的风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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| Synonyms |
5-Carbamoyl-5H-dibenz(bf)azepine Carbamazepine (substance) TEGretol Carbamazepen Carbamazepin 5H-Dibenz(bf)azepine-5-carboxamide Carbamazepine 169864 Carbamazepine Anhydrous Carbamazepina 5-Carbamyl-5H-dibenzo(bf)azepine CBZ Carbamazepinum 5-Carbamoyl-5H-dibenzo(bf)azepine Carbamazepine-containing product Carbamazépine 298-46-4 Product containing carbamazepine (medicinal product) 5-carbamoyl-5H-dibenz[bf]azepine Epitol Finlepsin Carbamazepine Dihydrate Carbamazepine Hydrochloride Neurotol Carbamazepine L-Tartrate (4:1) Carbamazepine Acetate Carbamazepine Sulfate (2:1) Carbamazepine Phosphate Carbazepin Amizepine |
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| subClassOf |