loading...| Preferred Name |
Clobazam |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass24cf80d2_8426_4e0b_a998_d5f49c7e12bb |
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| China_expert_opinion_2013 |
几乎所有AEDs都可通过血液进入母乳，使接受母乳喂养的婴儿间接获得AEDs。但目前普遍认为母乳喂养利大于弊，故提倡母乳喂养。母乳中AEDs浓度既受母亲血药浓度的影响，也受AEDs母乳通过率的影响，故母亲在哺乳期应服用可控制癫痫发作的AEDs最小剂量，同时应选择母乳通过率较低的药物以降低对婴儿的影响，如拉莫三嗪、氯巴占、奥卡西平等。 "关于成人癫痫患者长程管理的专家共识." 中华神经科杂志 .07(2013):496-499. |
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| Chinese |
氯巴占 |
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| label |
Clobazam |
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| MESH_Definition |
A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX-GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY. |
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| NCIt_Definition |
A 1,5-benzodiazepine and partial gamma-aminobutyric acid (GABA) receptor agonist, with anxiolytic, sedative, and anticonvulsant activities. Clobazam binds to a specific site, distinct from the inhibitory neurotransmitter GABA binding site, on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the opening of chloride-channels. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and a decrease in neuronal excitability. |
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| prefLabel |
Clobazam |
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| ROCG_Guidance |
[GRADES OF RECOMMENDATION:D] Long-acting benzodiazepines such as clobazam can be considered if there is a very high risk of seizures in the peripartum period. 【推荐等级：D】如果WWE在围产期癫痫发作的风险很高，可以考虑服用长效苯二氮卓类药物，如氯巴占。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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| Synonyms |
1-phenyl-5-methyl-8-chloro-1245-tetrahydro-24-dioxo-3H-15-benzodiazepine CLOBAZAM Frisium Product containing clobazam (medicinal product) 7-Chloro-1-methyl-5-phenyl-15-dihydro-benzo[b][14]diazepine-24-dione cloBAZam Clobazam (substance) Clobazam-containing product Onfi clobazam 1-Phenyl-5-methyl-8-chloro-1245- tetrahydro-24-diketo-3H-15-benzodiazepine Clobazamum 1H-15-Benzodiazepine-24(3H5H)-dione 7-chloro-1-methyl-5-phenyl- Urbanol Clobazam |
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| subClassOf |