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Combined Phenotype Ontology
Last uploaded:
November 4, 2024
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| Preferred Name | dexverapamil | |
| Synonyms |
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| Definitions |
A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_77734 |
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| definition |
A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
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| has characteristic | ||
| has role | ||
| in_subset | ||
| is_conjugate_base_of | ||
| is_enantiomer_of | ||
| label |
dexverapamil
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| prefixIRI |
CHEBI:77734
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| prefLabel |
dexverapamil
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| subClassOf |
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