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Sepsis Ontology
Last uploaded:
May 14, 2024
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| Preferred Name | Fentanyl | |
| Synonyms |
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| ID |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Fentanyl |
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| definition |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability.
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| label |
Fentanyl
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| prefixIRI |
Fentanyl
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| prefLabel |
Fentanyl
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| reference | ||
| Synonyms |
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
Abstral
Duragesic
FENTANYL
Fentanyl
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| subClassOf |
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Analgesic_Agent |
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