loading...| Preferred Name | Pregabalin | |
| Synonyms |
3-(Aminomethyl)-5-methyl-hexanoic Acid 3-Isobutyl GABA CI 1008 Lyrica PD 144723 |
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| Definitions |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C64625 |
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| database cross reference |
NCIT:C64625 |
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| definition |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
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| definition source | ||
| existence in other ontologies |
Sufficient |
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| hasExactSynonym |
3-(Aminomethyl)-5-methyl-hexanoic Acid 3-Isobutyl GABA CI 1008 Lyrica PD 144723 |
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| in guideline | ||
| prefixIRI |
NCIT:C64625 |
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| prefLabel |
Pregabalin |
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| previous identifier |
SCDO:0008454 |
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| rdfs:label |
Pregabalin |
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| skos:prefLabel |
Pregabalin |
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| treats | ||
| subClassOf |