Link to this page
Radiation Oncology Ontology
Last uploaded:
June 19, 2018
Jump to:
| Preferred Name | Teniposide | |
| Synonyms |
|
|
| Definitions |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C857 |
|
| definition |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)
|
|
| isDefinedBy | ||
| label |
Teniposide
|
|
| prefixIRI |
ncit:C857
|
|
| prefLabel |
Teniposide
|
|
| seeAlso |
EuroCAT Umbrella Protocol for NSCLC
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping