Preferred Name |
Epipodophyllotoxin Compound |
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Synonyms |
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Definitions |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 |
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definition |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
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isDefinedBy | ||
label |
Epipodophyllotoxin Compound |
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prefixIRI |
ncit:C1331 |
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prefLabel |
Epipodophyllotoxin Compound |
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subClassOf |
Delete | Mapping To | Ontology | Source |
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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | NCIT | SAME_URI | |
http://purl.obolibrary.org/obo/NCIT_C1331 | BERO | LOOM | |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | NCIT | LOOM |