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Radiation Oncology Ontology
Last uploaded:
June 19, 2018
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| Preferred Name | Epipodophyllotoxin Compound | |
| Synonyms |
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| Definitions |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 |
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| definition |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
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| isDefinedBy | ||
| label |
Epipodophyllotoxin Compound
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| prefixIRI |
ncit:C1331
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| prefLabel |
Epipodophyllotoxin Compound
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| subClassOf |
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| Mapping To | Ontology | Source |
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| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | NCIT | SAME_URI |
| http://purl.obolibrary.org/obo/NCIT_C1331 | BERO | LOOM |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1331 | NCIT | LOOM |