loading...| Preferred Name |
Charcot-Marie-Tooth disease |
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| Synonyms |
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| ID |
http://localhost/plosthes.2017-1#11574 |
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| alpha |
Charcot-Marie-Tooth disease |
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| broader | ||
| homepage |
http://journals.plos.org/plosone/browse/charcot-marie-tooth_disease |
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| prefLabel |
Charcot-Marie-Tooth disease |
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| Previous_Classification |
60.50.60.30^Charcot-Marie-Tooth disease|60.280.270.20.10^Charcot-Marie-Tooth disease |
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| scopeNote |
Charcot-Marie-Tooth Disease, or CMT, is a group of inherited disorders that affect the peripheral nerves, which are the nerves outside the brain and spinal cord. There are more than 70 kinds of CMT. Each kind is caused by a different kind of mutation, and more causes are being discovered every year. CMT is just one kind of neuropathy (also called peripheral neuropathy), meaning simply that the peripheral nerves are damaged. There are many other causes of neuropathy, including the most common cause—diabetes. CMT affects about 2.8 million people worldwide, of all races and ethnic groups. http://www.cmtausa.org/understanding-cmt/what-is-cmt/ A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy ( HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. Unique ID: D002607 https://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?mode=&index=2487&field=all&HM=&II=&PA=&form=&input= RD |
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| status |
Accepted |
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| Synonym |