The Prescription of Drugs Ontology

Last uploaded: September 4, 2020
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Preferred Name

Hydrochlorothiazide
Synonyms

hydrochlorothiazidum

hidroclorotiazida

Esidrix (TN)

hydrochlorothiazide

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Definitions

A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
ID

http://purl.obolibrary.org/obo/CHEBI_5778
alternative term

hydrochlorothiazidum

hidroclorotiazida

Esidrix (TN)

hydrochlorothiazide

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
bearer_of

http://purl.obolibrary.org/obo/CHEBI_35498

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_78298
charge

0
database_cross_reference

HMDB:HMDB0001928

KEGG:C07041

PMID:24849193

CAS:58-93-5

KEGG:D00340

Drug_Central:1385

Wikipedia:Hydrochlorothiazide

Reaxys:625101

PMID:24055851

PDBeChem:HCZ

LINCS:LSM-5308

PMID:24657333

DrugBank:DB00999
formula

C7H8ClN3O4S2
has role

http://purl.obolibrary.org/obo/CHEBI_35498

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_78298
has_exact_synonym

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
has_obo_namespace

chebi_ontology
has_related_synonym

hydrochlorothiazidum

hidroclorotiazida

Esidrix (TN)

hydrochlorothiazide
has_RxCUI

5487
id

CHEBI:5778
in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR
inchi

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
inchikey

JZUFKLXOESDKRF-UHFFFAOYSA-N
is bearer of

http://purl.obolibrary.org/obo/DRON_00000059
label

hydrochlorothiazide

Hydrochlorothiazide
mass

297.73900
monoisotopicmass

296.96448
notation

CHEBI:5778
prefixIRI

CHEBI:5778
prefLabel

Hydrochlorothiazide
smiles

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl
textual definition

A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
subClassOf

http://purl.obolibrary.org/obo/CHEBI_35358

http://purl.obolibrary.org/obo/CHEBI_36683

http://purl.obolibrary.org/obo/CHEBI_50265
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http://purl.obolibrary.org/obo/CHEBI_5778 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 ECTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5778 OBA SAME_URI
http://purl.bioontology.org/ontology/NDFRT/N0000145995 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00999 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.135.261.476 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0020261 HFO LOOM
http://purl.obolibrary.org/obo/OMIT_0007993 OMIT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017425 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020261 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.174.261.476 RH-MESH LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Hydrochlorothiazide SEPON LOOM
http://purl.bioontology.org/ontology/ATC/C03AA03 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D006852 BERO LOOM
http://www.co-ode.org/ontologies/galen#Hydrochlorothiazide GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6347 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.655.500.261.476 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/b26.. RCD LOOM
http://www.ifomis.org/acgt/1.0#Hydrochlorothiazide ACGT-MO LOOM
rgo:24939 GAMUTS LOOM
http://purl.bioontology.org/ontology/MESH/D006852 MESH LOOM
http://stirdf.jst.go.jp/id/200907079016032480 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 OBA LOOM
http://purl.bioontology.org/ontology/SNMI/C-72260 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387525002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/5487 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29098 NCIT LOOM
http://purl.obolibrary.org/obo/XCO_0000899 XCO LOOM
http://purl.obolibrary.org/obo/dinto_DB00999 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017615 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145995 OCVDAE LOOM
http://purl.obolibrary.org/obo/NCIT_C29098 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP16160-1 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060558 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/002294 NDDF LOOM
http://purl.jp/bio/4/id/200906026825052777 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006852 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00999 MDM LOOM