Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

isoflurane
Synonyms

Aerrane

1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (SN); 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

Forane

Isoflo

Definitions

A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake and it may potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65978" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65978" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000752236

altLabel

Aerrane

1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (SN); 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

Forane

Isoflo

CAS Registry

26675-46-7

cui

C3651895

C0308273

C0306242

C0022180

DATE FIRST PUBLISHED

2013-09-05

Date last modified

2013-09-05

definition

A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake and it may potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65978" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65978" NCI Thesaurus)

LT

TRD

NCI ID

C65978

notation

CDR0000752236

ORIG STY

Drug/agent

prefLabel

isoflurane

tui

T109

T121

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/RCD/x03mj RCD CUI
http://purl.bioontology.org/ontology/RXNORM/92754 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387368002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-D1151 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-C1996 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D007530 MESH CUI
http://purl.bioontology.org/ontology/NDDF/001391 NDDF CUI
http://purl.bioontology.org/ontology/RCD/o25.. RCD CUI
http://purl.bioontology.org/ontology/LNC/LP17885-2 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147364 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4019107 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-6A116 SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/6026 RXNORM CUI
http://purl.bioontology.org/ontology/ATC/N01AB06 ATC CUI
http://purl.bioontology.org/ontology/CSP/1372-8195 CRISP CUI
http://purl.bioontology.org/ontology/SCTSPA/387368002 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/MTHU024731 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/66492008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006307 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D007530 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/66492008 SCTSPA CUI
http://purl.obolibrary.org/obo/CHEBI_6015 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387368002 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016613 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6951 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D007530 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/001391 NDDF LOOM
http://stirdf.jst.go.jp/id/200907015777536998 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6015 EFO LOOM
http://purl.bioontology.org/ontology/RCD/o25.. RCD LOOM
http://purl.jp/bio/4/id/200906042827771555 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP17885-2 LOINC LOOM
http://purl.obolibrary.org/obo/XCO_0000109 XCO LOOM
http://id.nlm.nih.gov/mesh/D007530 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147364 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D007530 BERO LOOM
https://go.drugbank.com/drugs/DB00753 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4019107 VANDF LOOM
http://www.co-ode.org/ontologies/galen#Isoflurane GALEN LOOM
http://psink.de/scio/Isoflurane SCIO LOOM
http://www.pepathway.org/peo/1.2#isoflurane PE-O LOOM
http://purl.bioontology.org/ontology/SNMI/C-6A116 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0008645 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/6026 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/N01AB06 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022180 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007530 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/1372-8195 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.355.601.570 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65978 NCIT LOOM
http://www.drugbank.ca/drugs/DB00753 FTC LOOM
http://purl.obolibrary.org/obo/NCIT_C65978 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024731 LOINC LOOM