Preferred Name |
lacosamide |
|
Synonyms |
|
|
Definitions |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse and modifies axon number, length, and neuronal polarity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C83859" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C83859" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000712043 |
|
CAS Registry |
175481-36-4 |
|
cui |
C0893761 |
|
DATE FIRST PUBLISHED |
2011-09-15 |
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Date last modified |
2011-09-19 |
|
definition |
A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse and modifies axon number, length, and neuronal polarity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C83859" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C83859" NCI Thesaurus) |
|
NCI ID |
C83859 |
|
notation |
CDR0000712043 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
lacosamide |
|
tui |
T109 T121 |