loading...| Preferred Name | ethambutol | |
| Synonyms |
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| Definitions |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61755" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61755" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000701810 |
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| CAS Registry |
74-55-5 |
|
| cui |
C0014964 |
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| DATE FIRST PUBLISHED |
2011-06-06 |
|
| definition |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61755" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61755" NCI Thesaurus) |
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| NCI ID |
C61755 |
|
| notation |
CDR0000701810 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ethambutol |
|
| tui |
T109 T121 |