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Physician Data Query
| Preferred Name | metoprolol | |
| Synonyms |
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| Definitions |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61845" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000694582 |
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| CAS Registry |
37350-58-6
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| cui |
C0025859
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| DATE FIRST PUBLISHED |
2011-01-28
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| Date last modified |
2011-01-28
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|
| definition |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61845" NCI Thesaurus)
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| NCI ID |
C61845
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| notation |
CDR0000694582
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| ORIG STY |
Drug/agent
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| prefLabel |
metoprolol
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| tui |
T109 T121
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