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Physician Data Query
Last uploaded:
August 27, 2019
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| Preferred Name | ethosuximide | |
| Synonyms |
Zarontin 3-ethyl-3-methylpyrrolidine-2,5-dione |
|
| Definitions |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47523" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47523" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000694263 |
|
| altLabel |
Zarontin 3-ethyl-3-methylpyrrolidine-2,5-dione
|
|
| CAS Registry |
77-67-8
|
|
| cui |
C0699966 C0015043
|
|
| DATE FIRST PUBLISHED |
2011-01-21
|
|
| Date last modified |
2011-01-21
|
|
| definition |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47523" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47523" NCI Thesaurus)
|
|
| LT |
TRD
|
|
| NCI ID |
C47523
|
|
| notation |
CDR0000694263
|
|
| NSC Code |
64013
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
ethosuximide
|
|
| tui |
T109 T121
|
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