loading...| Preferred Name | valsartan | |
| Synonyms |
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine CGP 48933 Diovan L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- |
|
| Definitions |
An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47781" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000464172 |
|
| altLabel |
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine CGP 48933 Diovan L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- |
|
| CAS Registry |
137862-53-4 |
|
| cui |
C0719949 C0216784 C0527644 |
|
| DATE FIRST PUBLISHED |
2006-01-25 |
|
| Date last modified |
2006-06-30 |
|
| definition |
An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47781" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47781 |
|
| notation |
CDR0000464172 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
valsartan |
|
| tui |
T109 T121 |