loading...| Preferred Name |
mantle cell lymphoma |
|
| Synonyms |
lymphoma, mantle cell MCL |
|
| Definitions |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4337" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C4337" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042534 |
|
| altLabel |
lymphoma, mantle cell Mantle Zone Lymphoma MCL |
|
| cui |
C4721414 |
|
| Date last modified |
2004-08-03 |
|
| definition |
An aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4337" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C4337" NCI Thesaurus) |
|
| Legacy PDQ ID |
6178 |
|
| NCI ID |
C4337 |
|
| notation |
CDR0000042534 |
|
| ORIG STY |
Neoplasm diagnosis |
|
| prefLabel |
mantle cell lymphoma |
|
| tui |
T191 |
|
| subClassOf |