Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

phenobarbital
Synonyms

PHENO

5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Definitions

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C739" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C739" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042405
altLabel

PHENO

5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS Registry

50-06-6
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000043603
cui

C0031412
definition

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C739" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C739" NCI Thesaurus)
Legacy PDQ ID

5661
NCI ID

C739
notation

CDR0000042405
NSC Code

128143

9848
ORIG STY

Drug/agent
prefLabel

phenobarbital
tui

T109

T121
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http://purl.bioontology.org/ontology/RXNORM/8134 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/dn7.. RCD CUI
http://purl.bioontology.org/ontology/NDDF/001406 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4017422 VANDF CUI
http://purl.bioontology.org/ontology/RCD/X796h RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373505007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/51073002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D010634 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU066205 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/51073002 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/LP14729-5 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/373505007 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005893 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-61320 SNMI CUI
http://purl.bioontology.org/ontology/LNC/LA28622-1 LOINC CUI
http://purl.bioontology.org/ontology/MESH/D010634 MESH CUI
http://purl.bioontology.org/ontology/ATC/N03AA02 ATC CUI
http://purl.bioontology.org/ontology/LNC/MTHU060452 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000145810 NDFRT CUI
http://purl.bioontology.org/ontology/CSP/2517-5803 CRISP CUI
http://purl.bioontology.org/ontology/RXNORM/8134 RXNORM LOOM
http://www.case.edu/EpSO.owl#Phenobarbital MEPO LOOM
http://purl.bioontology.org/ontology/CPT/80184 CPT LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass76d85774_6873_492b_9f37_09bcdb4cce7b WWECA LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassbfa7f9a0_dd19_4e74_8927_3da690b16ab9 WWECA LOOM
http://purl.jp/bio/4/id/200906049799167030 IOBC LOOM
rgo:19877 GAMUTS LOOM
http://purl.obolibrary.org/obo/XCO_0001203 XCO LOOM
http://purl.bioontology.org/ontology/VANDF/4017422 VANDF LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Phenobarbital APAONTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DRON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031412 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010634 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01174 MDM LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Phenobarbital ESSO LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Phenobarbital MEPO LOOM
http://purl.obolibrary.org/obo/NCIT_C739 BERO LOOM
http://purl.obolibrary.org/obo/MESH_D010634 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373505007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU066205 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9598 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C739 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP14729-5 LOINC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClasscb7a89af_955f_4b5d_a48a_77e66e590119 WWECA LOOM
http://www.drugbank.ca/drugs/DB01174 FTC LOOM
http://www.projecthalo.com/aura#Phenobarbital AURA LOOM
http://www.case.edu/EpilepsyOntology.owl#Phenobarbital EPSO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018447 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-61320 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LA28622-1 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D010634 MESH LOOM
http://purl.bioontology.org/ontology/ATC/N03AA02 ATC LOOM
http://stirdf.jst.go.jp/id/200907090523280154 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0011623 OMIT LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Phenobarbital FRMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060452 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145810 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.698.253.650 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/2517-5803 CRISP LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassdb8cba67_a0ea_4eb7_8881_c253380c2609 WWECA LOOM