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Physician Data Query
| Preferred Name | clarithromycin | |
| Synonyms |
Abbott-56268 Biaxin 6-O-Methylerythromycin CLARITH |
|
| Definitions |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1054" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1054" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042308 |
|
| altLabel |
Abbott-56268 Biaxin 6-O-Methylerythromycin CLARITH
|
|
| CAS Registry |
81103-11-9
|
|
| Component of | ||
| cui |
C0055856 C0701281 C0701282
|
|
| Date last modified |
2006-07-31
|
|
| definition |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1054" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1054" NCI Thesaurus)
|
|
| Legacy PDQ ID |
5556
|
|
| LT |
TRD
|
|
| NCI ID |
C1054
|
|
| notation |
CDR0000042308
|
|
| NSC Code |
643733
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
clarithromycin
|
|
| tui |
T109 T195
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