Link to this page
Physician Data Query
| Preferred Name | lorazepam | |
| Synonyms |
Ativan 7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-Hydroxy-1,4- benzodiazepin-2-one |
|
| Definitions |
A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C619" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C619" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039757 |
|
| altLabel |
Ativan 7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-Hydroxy-1,4- benzodiazepin-2-one
|
|
| CAS Registry |
846-49-1
|
|
| cui |
C0024002 C0699194
|
|
| definition |
A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C619" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C619" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2418
|
|
| LT |
TRD
|
|
| NCI ID |
C619
|
|
| notation |
CDR0000039757
|
|
| NSC Code |
289758
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
lorazepam
|
|
| tui |
T109 T121
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |