Link to this page
Physician Data Query
| Preferred Name | verapamil | |
| Synonyms |
Verapamil SR alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile |
|
| Definitions |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C928" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C928" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039730 |
|
| altLabel |
Verapamil SR alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
|
|
| CAS Registry |
52-53-9
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041262 http://purl.bioontology.org/ontology/PDQ/CDR0000041513 http://purl.bioontology.org/ontology/PDQ/CDR0000041523 http://purl.bioontology.org/ontology/PDQ/CDR0000041095 http://purl.bioontology.org/ontology/PDQ/CDR0000041462 http://purl.bioontology.org/ontology/PDQ/CDR0000040143 |
|
| cui |
C1527129 C0042523
|
|
| Date last modified |
2006-12-19
|
|
| definition |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C928" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C928" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2392
|
|
| LT |
TRD
|
|
| NCI ID |
C928
|
|
| notation |
CDR0000039730
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
verapamil
|
|
| tui |
T109 T121
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |