Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

spironolactone
Synonyms

SC 9420

17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate

SPL

Spiroctan

Aldactone
Definitions

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039444
altLabel

SC 9420

17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate

SPL

Spiroctan

Aldactone
CAS Registry

52-01-7
cui

C0591054

C0037982

C0701468

C0592132
Date last modified

2015-10-02
definition

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus)
IND Code

11222
Legacy PDQ ID

2079
LT

TRD
NCI ID

C840
notation

CDR0000039444
NSC Code

150399
ORIG STY

Drug/agent
prefLabel

spironolactone
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/151317 RXNORM CUI
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP CUI
http://purl.bioontology.org/ontology/MSHFRE/D013148 MSHFRE CUI
http://purl.bioontology.org/ontology/RCD/x02rO RCD CUI
http://purl.bioontology.org/ontology/SNMI/C-C10CE SNMI CUI
http://purl.bioontology.org/ontology/RCD/x02T5 RCD CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D013148 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/387078006 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/MTHU003227 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146234 NDFRT CUI
http://purl.bioontology.org/ontology/RCD/b43.. RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/13929005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/13929005 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/9997 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387078006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005900 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/C03DA01 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4017881 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-72420 SNMI CUI
http://purl.bioontology.org/ontology/LNC/LP16280-7 LOINC CUI
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/NDDF/002211 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/MESH/D002191 MESH CUI
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 CHEBI LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DRON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0037982 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.855 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D013148 BERO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840 NCIT LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02645 MIO LOOM
http://www.drugbank.ca/drugs/DB00421 FTC LOOM
http://www.ifomis.org/acgt/1.0#Spironolactone ACGT-MO LOOM
http://purl.obolibrary.org/obo/NCIT_C840 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003227 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146234 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/b43.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/9997 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387078006 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11637 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 ECTO LOOM
http://stirdf.jst.go.jp/id/200907023665510166 IOBC LOOM
http://purl.jp/bio/4/id/200906028579154843 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/C03DA01 ATC LOOM
https://go.drugbank.com/drugs/DB00421 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.679 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0014028 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013148 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4017881 VANDF LOOM
http://www.co-ode.org/ontologies/galen#Spironolactone GALEN LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017157 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-72420 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LP16280-7 LOINC LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Spironolactone SEPON LOOM
http://bmi.utah.edu/ontologies/hfontology/C0037982 HFO LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass33ee744e_a8a5_48fe_b3c5_f00b5c868cb8 WWECA LOOM
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP LOOM
http://purl.bioontology.org/ontology/MESH/D013148 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002211 NDDF LOOM