loading...| Preferred Name | Toxic epidermal necrolysis | |
| Synonyms |
Lyell syndrome |
|
| Definitions |
An extended form of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum characterized by destruction and detachment of the skin epithelium, involving 30% or more of the body surface area, and mucous membranes. Onset usually occurs 4-28 days after administration of the causal medication and is most frequently associated with anticonvulsants, antibacterial sulfonamides, allopurinol, nevirapine, and oxicams (non-steroidal anti-inflammatory drugs), but many other medications have also been implicated. The disease is not induced by medication in 15% of cases. Histology is characterized by an epidermal necrolysis. Multiple disabling long-term sequelae (especially cutaneous, ocular and psychological) are frequent. |
|
| ID |
http://www.orpha.net/ORDO/Orphanet_537 |
|
| alternative_term |
Lyell syndrome |
|
| definition |
An extended form of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum characterized by destruction and detachment of the skin epithelium, involving 30% or more of the body surface area, and mucous membranes. Onset usually occurs 4-28 days after administration of the causal medication and is most frequently associated with anticonvulsants, antibacterial sulfonamides, allopurinol, nevirapine, and oxicams (non-steroidal anti-inflammatory drugs), but many other medications have also been implicated. The disease is not induced by medication in 15% of cases. Histology is characterized by an epidermal necrolysis. Multiple disabling long-term sequelae (especially cutaneous, ocular and psychological) are frequent. |
|
| definition_citation |
Orphanet |
|
| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=537 |
|
| has_age_of_onset |
All ages |
|
| has_inheritance |
Not applicable |
|
| hasDbXref |
UMLS:C0014518 ICD-11:EB13.1 ICD-10:L51.2 MedDRA:10044223 |
|
| label |
Toxic epidermal necrolysis |
|
| notation |
Clinical subtype ORPHA:537 |
|
| part_of | ||
| prefixIRI |
ORDO:Orphanet_537 |
|
| prefLabel |
Toxic epidermal necrolysis |
|
| present_in |
Worldwide AND has_point_prevalence_range : Unknown |
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| treeView | ||
| subClassOf |