loading...| Preferred Name | Acute myelomonocytic leukemia | |
| Synonyms |
AMMoL AML M4 |
|
| Definitions |
A rare acute myeloid leukemia disorder characterized by increased blast cells (myeloblasts, monoblast, and/or promonoblasts), representing more than 20% of the total bone marrow (BM) or peripheral blood differential counts, with 20-80% of BM cells being of monocytic lineage. Clinical presentation is the result of bone marrow involvement and extramedullary infiltration by the leukemic cells and includes asthenia, pallor, fever, dizziness, respiratory symptoms, easy bruising, bleeding disorders, and neurological deficits. Gingival hyperplasia, organomegaly, especially hepatosplenomegaly, and lymphadenopathy may also be associated. |
|
| ID |
http://www.orpha.net/ORDO/Orphanet_517 |
|
| alternative_term |
AMMoL AML M4 |
|
| definition |
A rare acute myeloid leukemia disorder characterized by increased blast cells (myeloblasts, monoblast, and/or promonoblasts), representing more than 20% of the total bone marrow (BM) or peripheral blood differential counts, with 20-80% of BM cells being of monocytic lineage. Clinical presentation is the result of bone marrow involvement and extramedullary infiltration by the leukemic cells and includes asthenia, pallor, fever, dizziness, respiratory symptoms, easy bruising, bleeding disorders, and neurological deficits. Gingival hyperplasia, organomegaly, especially hepatosplenomegaly, and lymphadenopathy may also be associated. |
|
| definition_citation |
Orphanet |
|
| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=517 |
|
| has_age_of_onset |
Adult |
|
| has_inheritance |
Not applicable |
|
| hasDbXref |
ICD-11:2A60.33 MedDRA:10000890 ICD-10:C92.5 MeSH:D015479 UMLS:C0023479 |
|
| label |
Acute myelomonocytic leukemia |
|
| notation |
ORPHA:517 |
|
| part_of | ||
| prefixIRI |
ORDO:Orphanet_517 |
|
| prefLabel |
Acute myelomonocytic leukemia |
|
| present_in |
Europe AND has_point_prevalence_range : 1-9 / 1 000 000 Europe AND has_annual_incidence_average_value : 0.17 AND has_annual_incidence_range : 1-9 / 1 000 000 |
|
| treeView | ||
| subClassOf |