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Orphanet Rare Disease Ontology
Last uploaded:
July 3, 2024
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| Preferred Name | Neurofibroma | |
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| Definitions |
A rare benign peripheral nerve sheath tumor characterized by a well-demarcated intraneural or diffusely infiltrative extraneural space-occupying lesion consisting of Schwann cells, perineurial-like cells, and fibroblasts. It presents as a cutaneous nodule, a circumscribed mass in a peripheral nerve, a plexiform enlargement of a major nerve trunk, or with diffuse but localized involvement of skin and subcutaneous tissue. Multiple neurofibromas are typically associated with neurofibromatosis 1. Malignant transformation occurs almost exclusively in plexiform neurofibromas and neurofibromas of major nerves. |
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| ID |
http://www.orpha.net/ORDO/Orphanet_252183 |
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| definition |
A rare benign peripheral nerve sheath tumor characterized by a well-demarcated intraneural or diffusely infiltrative extraneural space-occupying lesion consisting of Schwann cells, perineurial-like cells, and fibroblasts. It presents as a cutaneous nodule, a circumscribed mass in a peripheral nerve, a plexiform enlargement of a major nerve trunk, or with diffuse but localized involvement of skin and subcutaneous tissue. Multiple neurofibromas are typically associated with neurofibromatosis 1. Malignant transformation occurs almost exclusively in plexiform neurofibromas and neurofibromas of major nerves.
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| definition_citation |
Orphanet
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| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=252183 |
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| hasDbXref |
ICD-11:2F3Y ICD-10:D36.1 MeSH:D009455 MedDRA:10029267 UMLS:C0027830
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| label |
Neurofibroma
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| notation |
ORPHA:252183
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| part_of | ||
| prefixIRI |
ORDO:Orphanet_252183
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| prefLabel |
Neurofibroma
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